In addition, since disturbance of cellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes (1). It thus may contribute to the sorting of heterogeneous cell types (3). Cadherin-20 is a cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells (1). Millions of users download 3D and 2D CAD files everyday. ![]() In mice, during embryogenesis, Cadherin-20 was found to be synthesized by the forebrain, anterior neural ridge, developing visual system, primitive external granular layer of the cerebellum and a subset of neural crest cells likely to develop into melanoblasts (3). Dassault Systèmes 3D ContentCentral is a free library of thousands of high quality 3D CAD models from hundreds of suppliers. Cadherin-20 is expressed in placenta, adult brain, and fetal brain (1). CAD / CAM / CIM / Radhakrishnan and Subramanian / New Age 3. ![]() Mature human Caderin-20 is 98% and 97% aa identical to mature mouse and rat Cadherin-20, respectively. Automation, Production systems & Computer integrated Manufacturing/ Groover/P.E 2. The ECD contains five cadherin domains, two calcium-binding sites, and four potential sites for N-linked glycosylation. Human Cadherin-20 is synthesized as a precursor that contains a 34 aa signal sequence, a 25 aa propeptide, a 560 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 161 aa cytoplasmic region (SwissProt # Q9HBT6). The extracellular cadherin domains bind Ca 2+ in order for correct protein folding and normal functioning to take place (1). Cadherins are calcium-dependent intercellular glycoproteins containing five extracellular cadherin repeats of about 110 amino acids (aa) with typical conserved sequences (1 - 2). ![]() Cadherin-20 is an 82 kDa (predicted) type II classical cadherin from the cadherin superfamily and one of three Cadherin 7-like genes located in a cluster on chromosome 18 (1, 4).
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